Digitalized design of cell factory enables green biomanufacturing

Authors

Fanze MENG, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, ChinaFollow
Rui CAO, School of Intelligence Science and Technology (School of Future Technology), Urumqi 830049, China
Bing HU, Institute of Biochemistry and Chemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology / Key Laboratory of Medicinal Molecular Science and Pharmaceutical Engineering, Beijing 100081, China
Lei QIN, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China
Chun LI, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; Institute of Biochemistry and Chemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology / Key Laboratory of Medicinal Molecular Science and Pharmaceutical Engineering, Beijing 100081, ChinaFollow

Keywords

new productive force; green biomanufacturing; cell factory; digitalization; synthetic biology

Document Type

Biomanufacturing: Retrospect and Prospects

Abstract

Green manufacturing is a modern manufacturing mode in the consideration of both environmental impact and efficiency of resource utilization, it represents a significant component of the “new productive force”. Centered on cell factories, green biomanufacturing leverages renewable resources to efficiently produce products that conform to the concepts of low-carbon, green, and sustainable development. The design of high-performance cell factories is pivotal for achieving efficient green biomanufacturing. Nevertheless, traditional cell factory design processes are complex, time-consuming, and labor-intensive. With advancements in artificial intelligence, digital-assisted cell factory design has emerged as a solution to save time and reduce costs. By integrating technologies such as database construction and updating, digital metabolic flux control design, digital retrosynthetic pathway design for target molecules, digital genetic circuit design, and fermentation process digital twin modeling, the full lifecycle digital design of cell factories can be achieved. This approach enables the rapid construction of high-performance cell factories, empowering green biomanufacturing.

First page

67

Last Page

78

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

References

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Recommended Citation

MENG, Fanze; CAO, Rui; HU, Bing; QIN, Lei; and LI, Chun (2024) "Digitalized design of cell factory enables green biomanufacturing," Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 40 : Iss. 1 , Article 7.
DOI: https://doi.org/10.16418/j.issn.1000-3045.20241228001
Available at: https://bulletinofcas.researchcommons.org/journal/vol40/iss1/7