Current status and prospect of industrial filamentous fungi in biomanufacturing

Authors

Zhiqiang DU, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, ChinaFollow
Ping MEN, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China
Yu ZHOU, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China; Institute for Smart Materials & Engineering, University of Jinan, Jinan 250022, China
Xuan ZHANG, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China
Xuenian HUANG, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China
Xuefeng LYU, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, ChinaFollow

Keywords

synthetic biology; biomanufacturing; industrial filamentous fungi; chassis cell factory; bio-based chemicals

Document Type

Biomanufacturing: Retrospect and Prospects

Abstract

Filamentous fungi, a critical class of industrial microorganisms pivotal to the biomanufacturing industry, has extensive applications in various fields such as pharmaceuticals, food, agriculture, and chemical materials, which are playing a vital role in human life. Recently, innovations in synthetic biology have further driven the application of industrial filamentous fungi in biomanufacturing, highlighting their critical role in this field. This article presents a comprehensive review of the recent progress in the field, covering the latest developments in genetic modification techniques for industrial filamentous fungi, successful cases of rational strain improvement strategies aimed to enhance the quality and efficiency of current product manufacturing processes, and innovative technologies that utilize industrial strains as chassis cells for the production of plant natural products, bio-based chemicals, and functional proteins. The review summarizes and analyzes the work that has been discussed, and explores the prospects and challenges for industrial filamentous fungi in biomanufacturing.

First page

36

Last Page

46

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

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Recommended Citation

DU, Zhiqiang; MEN, Ping; ZHOU, Yu; ZHANG, Xuan; HUANG, Xuenian; and LYU, Xuefeng (2024) "Current status and prospect of industrial filamentous fungi in biomanufacturing," Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 40 : Iss. 1 , Article 5.
DOI: https://doi.org/10.16418/j.issn.1000-3045.20241126005
Available at: https://bulletinofcas.researchcommons.org/journal/vol40/iss1/5