Current status and applications of microbial chassis strains for Chinese biomanufacturing industry

Authors

Guoqiang CHEN, School of Life Sciences, Tsinghua University, Beijing 100084, China; Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, ChinaFollow
Fuqing WU, School of Life Sciences, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China
Shuang ZHENG, School of Life Sciences, Tsinghua University, Beijing 100084, China
Jun DING, School of Life Sciences, Tsinghua University, Beijing 100084, China
Junting SHENG, School of Life Sciences, Tsinghua University, Beijing 100084, China

Keywords

microbial chassis; biomanufacturing; synthetic biology; new quality productive forces; extremophiles

Document Type

Biomanufacturing: Retrospect and Prospects

Abstract

Biomanufacturing is an important component of new quality productive forces, representing the commanding height of the new round of technological revolution and serving as a new engine for industrial transformation following information technology. It demonstrates vast application prospects in fields such as renewable energy, advanced materials, biomedicine, green food, and environmental protection. Biomanufacturing utilizes chassis microorganisms similar as “microchip” to produce various bioproducts via processes including chassis design and construction, large-scale cell cultivation, and product purifications. Most chassis microorganisms in biomanufacturing were not domestically identified. This study summarizes the types of common chassis microorganisms both domestically and internationally, as well as the current status of novel chassis microorganism development. It analyzes the primary issues and challenges faced by China in the development of chassis microorganisms. Furthermore, it focuses on the development of novel extremophilic microorganisms as novel chassis. We propose several points to promote the development of chassis microorganisms with independent IP in China, encompassing top-down designs for the 15th Five-Year Plan layout, platform construction, policy and regulatory frameworks, talent cultivation, regulatory mechanisms, legal protection, and evaluation systems.

First page

2

Last Page

13

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

References

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Recommended Citation

CHEN, Guoqiang; WU, Fuqing; ZHENG, Shuang; DING, Jun; and SHENG, Junting (2024) "Current status and applications of microbial chassis strains for Chinese biomanufacturing industry," Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 40 : Iss. 1 , Article 2.
DOI: https://doi.org/10.16418/j.issn.1000-3045.20241209006
Available at: https://bulletinofcas.researchcommons.org/journal/vol40/iss1/2