Bioprocess engineering and intelligent biomanufacturing

Authors

Guan WANG, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Qingdao New Energy Shandong Laboratory, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaFollow
Yingping ZHUANG, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Qingdao New Energy Shandong Laboratory, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaFollow

Keywords

bioprocess; biomanufacturing; intelligent sensing; intelligent analysis; intelligent control

Document Type

Biomanufacturing: Retrospect and Prospects

Abstract

In the era of rapid development of synthetic biology, biomanufacturing, as a bridge between life sciences and engineering technologies, is gradually demonstrating its extraordinary potential to reshape industrial landscapes. However, challenges such as production efficiency, cost control, and process monitoring still hinder the smooth transition from laboratory innovations to industrial-scale implementation. Intelligent biomanufacturing has emerged as a new form of productive force, offering innovative solutions to these problems. This study reviews the latest advances in bioprocess engineering and intelligent biomanufacturing, focusing on three key technological systems: intelligent sensing, intelligent analysis, and intelligent control. Intelligent sensing technology acts as the “eyes” of biological processes, enabling real-time, high-precision environmental monitoring. Intelligent analysis, as the “brain”, uncovers underlying patterns in data, providing decision-making insights. Intelligent control, the “commander”, precisely regulates bioprocesses to ensure efficient and stable operation. The integration of these three technologies significantly enhances the intelligence of biomanufacturing, providing powerful momentum to overcome industrialization bottlenecks. Looking ahead, intelligent biomanufacturing will continue to evolve through ongoing technological innovation and interdisciplinary collaboration, expanding its applications toward greater efficiency, intelligence, and sustainability, contributing to the progress and prosperity of human society.

First page

107

Last Page

115

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

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Recommended Citation

WANG, Guan and ZHUANG, Yingping (2024) "Bioprocess engineering and intelligent biomanufacturing," Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 40 : Iss. 1 , Article 10.
DOI: https://doi.org/10.16418/j.issn.1000-3045.20241127004
Available at: https://bulletinofcas.researchcommons.org/journal/vol40/iss1/10