Bulletin of Chinese Academy of Sciences (Chinese Version)
Keywords
gene editing; bibliometrics; technology composition; technology flow direction; technological innovation subject
Document Type
Article
Abstract
Gene editing technology is a very important bioengineering technology, which is widely used in biomedicine, biological environmental protection, and agricultural production. Based on the analysis of patents and articles related to gene editing, this study reveals the development status and trend of gene editing technology from the following aspects: Patent application and publication of major global institutions, overview of CRISPR technology patents, cooperation among patent inventors in various countries, analysis of technology flow direction, technology composition, and status of main innovation subjects. Countermeasures and suggestions on the original technology innovation, industrialization process, and international collaboration are put forward for researchers and decision makers in the related fields.
First page
1510
Last Page
1524
Language
Chinese
Publisher
Bulletin of Chinese Academy of Sciences
References
Gaj T, Gersbach C A, Barbas C F III. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends in Biotechnology, 2013, 31(7):397-405.
Gupta R M, Musunuru K. Expanding the genetic editing tool kit:ZFNs, TALENs, and CRISPR-Cas9. Journal of Clinical Investigation, 2014, 124(10):4154-4161.
LaFountaine J S, Fathe K, Smyth H D C. Delivery and therapeutic applications of gene editing technologies ZFNs, TALENs, and CRISPR/Cas9. International Journal of Pharmaceutics, 2015, 494(1):180-194.
Liu H, Liu C, Zhao Y H, et al. Comparing successful gene knock-in efficiencies of CRISPR/Cas9 with ZFNs and TALENs gene editing systems in bovine and dairy goat fetal fibroblasts. Journal of Integrative Agriculture, 2018, 17(2):406-414.
Shan Q W, Baltes N J, Atkins P, et al. ZFN, TALEN and CRISPR-Cas9 mediated homology directed gene insertion in Arabidopsis:A disconnect between somatic and germinal cells. Journal of Genetics and Genomics, 2018, 45(12):681-684.
Jaworski A, Dobrowolska A. Organization of the bacterial interference RNAi-like system (CRISPR-CAS) and its role against bacteriophages. Postepy Mikrobiologii, 2009, 48(1):23-30.
Carte J, Pfister N T, Compton M M, et al. Binding and cleavage of CRISPR RNA by Cas6. RNA, 2010, 16(11):2181-2188.
Babu M H, Beloglazova N, Flick R, et al. A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Molecular Microbiology, 2011, 79(2):484-502.
Makarova K S, Haft D H, Barrangou R, et al. Evolution and classification of the CRISPR-Cas systems. Nature Reviews Microbiology, 2011, 9(6):467-477.
Burley K M, Sedgley C M. CRISPR-Cas, a prokaryotic adaptive immune system, in endodontic, oral, and multidrugresistant hospital-acquired Enterococcus faecalis. Journal of Endodontics, 2012, 38(11):1511-1515.
Weinberger A D, Gilmore M S. CRISPR-Cas:To take up DNA or not-That is the question. Cell Host & Microbe, 2012, 12(2):125-126.
Capecchi M R. Culturing cells having a modification of a target DNA sequence in its genome, useful for producing transgenic animals or for manipulating plant cells, comprises transforming cells with a positive-negative selector vector: US, 781559.1997-01-09.
Routman K D. Universities and industry square off over recombinant-DNA ownership rights and research talent. Drug & Cosmetic Industry, 1981, 128(3):40
Blum B, Bakalara N, Simpson L. A model for RNA editing in kinetoplastid mitochondria:"Guide" RNA molecules transcribed from maxicircle DNA provide the edited information. Cell, 1990, 60(2):189-198.
Zhang B B, Xia Q, Wang Q, et al. Detecting and typing target DNA with a novel CRISPR-typing PCR (ctPCR) technique. Analytical Biochemistry, 2018, 561/562:37-46.
Alkan F, Wenzel A, Anthon C, et al. CRISPR-Cas9 offtargeting assessment with nucleic acid duplex energy parameters. Genome Biology, 2018, 19(1):177-189.
Lee S H, Kim S, Hur J K. CRISPR and target-specific DNA endonucleases for efficient DNA knock-in in Eukaryotic genomes. Molecules and Cells, 2018, 41(11):943-952.
Bewg W P, Ci D, Tsai C J. Genome editing in trees:From multiple repair pathways to long-term stability. Frontiers in Plant Science, 2018, 9:1732.
Otsuka K, Tomita M. Concurrent live imaging of DNA doublestrand break repair and cell-cycle progression by CRISPR/Cas9-mediated knock-in of a tricistronic vector. Scientific Reports, 2018, 8(1):17309.
Slyskova J, Sabatella M, Ribeiro-Silva C, et al. Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage. Nucleic Acids Research, 2018, 46(18):9537-9549.
Zhu W, Saw D, Weiss M, et al. Induction of brain arteriovenous malformation through CRISPR/Cas9-mediated somatic Alk1 gene mutations in adult mice. Translational Stroke Research, 2019, 10(5):557-565.
Recommended Citation
Xiufang, SONG; Xuemei, WEI; Lili, ZHENG; Yajuan, ZHAO; Kexin, ZHANG; Chunguang, LIU; and Weihua, XU
(2020)
"Analysis and Review on Gene Editing,"
Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 35
:
Iss.
12
, Article 10.
DOI: https://doi.org/10.16418/j.issn.1000-3045.20200601001
Available at:
https://bulletinofcas.researchcommons.org/journal/vol35/iss12/10