persistent organic pollutants; artificial chemicals; risk assessment; health effects; screening and identification theory; analysis method; environmental behavior
Since the twentieth century, the health hazards caused by chemical pollutants have become increasingly prominent. Tens of thousands of high throughput chemicals have entered into the environment along with the massive production and use, raising emerging scientific issues for research in environmental science related fields. In this article, background and scientific significance of establishing the research direction on identification of novel organic pollutants are introduced. Basic principles of discriminating molecular structures and environmental behaviors of pollutant candidates with regard to the characteristics of persistent organic pollutants are discussed. Technical strategy and advantages of the established analytical frameworks, including quantitative structure-property relationship model prediction, suspect/non-targeted analysis, and biological effect-directed analysis, are further described. In-depth exploration on occurrence, behavior and effects of novel organic pollutants will play a crucial supportive role in leading the direction of discipline development, improving chemical risk assessment criterions, and revealing the toxicity and hazard mechanisms of environmental pollutants.
Bulletin of Chinese Academy of Sciences
江桂斌, 阮挺, 曲广波.发现新型有机污染物的理论与方法.北京:科学出版社, 2019:66.
United Nations Environmental Programme. Stockholm Convention.[2020-09-01]. http://pops.int.
陈会明.化学品安全监管应提升为国家战略.检验检疫学刊, 2012, 22(1):1-13.
Muir D C G, Howard P H. Are there other persistent organic pollutants? A challenge for environmental chemists. Environmental Science & Technology, 2006, 40(23):7157-7166.
United Nations Environmental Programme. Final act of the Conference of Plenipotentiaries on the Stockholm Convention on Persistent Organic Pollutants. Geneva:United Nations Environmental Programme, 2001:44.
Environment Canada. Toxic Substances Management Policy. Ottawa:Government of Canada, 1995:8.
United States Environmental Protection Agency. Proposed category for persistent, bioaccumulative, and toxic chemicals. Federal Register, 1998, 63:53417-53423.
United States Environmental Protection Agency. Kowwin Technique Note, Estimation Program Interface (EPI) Suite, V 4.10. Washington DC:United States Environmental Protection Agency, 2007.
Wegmann F, Cavin L, MacLeod M, et al. The OECD software tool for screening chemicals for persistence and long-range transport potential. Environmental Modelling and Software, 2009, 24(2):228-237.
Rostkowski P, Haglund P, Aalizadeh R, et al. The strength in numbers:Comprehensive characterization of house dust using complementary mass spectrometric techniques. Analytical and Bioanalytical Chemistry, 2019, 411(10):1957-1977.
林泳峰, 阮挺, 江桂斌.发现新型化学污染物的技术途径.中国科学:化学, 2018, 48(10):1151-1162.
Escher B I, Stapleton H M, Schymanski E L. Tracking complex mixtures of chemicals in our changing environment. Science, 2020, 367:388-392.
Ruan T, Lin Y F, Wang T, et al. Identification of novel polyfluorinated ether sulfonates as PFOS alternatives in municipal sewage sludge in China. Environmental Science & Technology, 2015, 49(11):6519-6527.
Schuetzle D, Lewtas J. Bioassay-directed chemical analysis in environmental research. Analytical Chemistry, 1986, 58(11):1060A-1075A.
Qu G B, Shi J B, Wang T, et al. Identification of tetrabromobisphenol A diallyl ether as an emerging neurotoxicant in environmental samples by bioassay-directed fractionation and HPLC-APCI-MS/MS. Environmental Science & Technology, 2011, 45(11):5009-5016.
Tice R R, Austin C P, Kavlock R J, et al. Improving the human hazard characterization of chemicals:A Tox21 update. Environmental Health Perspectives, 2013, 121(7):756-765.
Hollender J, Schymanski E L, Singer H P, et al. Nontarget screening with high resolution mass spectrometry in the environment:Ready to go? Environmental Science & Technology, 2017, 51(20):11505-11512.
Vermeulen R, Schymanski E L, Barabási A L, et al. The exposome and health:Where chemistry meets biology. Science, 2020, 367(6476):392-396.
冷曙光, 郑玉新.基于生物标志物和暴露组学的环境与健康研究.中华疾病控制杂志, 2017, 21(11):1079-1081.
Ting, RUAN and Guibin, JIANG
"Basic Theory and Analytical Methodology for Identification of Novel Environmental Organic Pollutants,"
Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 35
, Article 3.
Available at: https://bulletinofcas.researchcommons.org/journal/vol35/iss11/3