antimalarial drug; artemisinin; artemisinin derivatives; 523 mission
Artemisinin and its derivatives and compounds has become a world-famous anti-malaria drug nowadays. Artemisinin and its derivatives, as the drug of first choice for the treatment of malaria worldwide, have relieved the suffering of millions of malaria patients. Therefore, Youyou Tu, who has made outstanding contributions to the development of artemisinin, became the first Chinese native scientist to receive the Nobel Prize in Physiology or Medicine. The discovery of artemisinin was made in a fairly complex social and cultural environment. This is an typical example of a mission-driven process accompnied by the development of scientific research and filed progress. The discovery of artemisin was the result of mutual-interaction as well as mutual-promotion of national needs and scientific research. Reviewing the history of artemisinin research and development, and examining how to achieve breakthroughs through organized research collaboration and multi-institutional advantages integration in the context of relatively backward equipment and technical conditions, this article is aimed to explore the interactions of social, political, cultural factors, basic research and technology development. The experience and lessons from this research are valuable for futher development.
Bulletin of Chinese Academy of Sciences
The Nobel Prize Organisation. Discovery of Artemisinin-A Gift from Traditional Chinese Medicine to the World.[2019-05-18]. https://www.nobelprize.org/prizes/medicine/2015/tu/lecture/.
黎润红. "五二三任务"与青蒿抗疟作用的再发现.中国科技史杂志, 2011, 32(4):488-500.
中国科学院生物物理研究所青蒿素协作组.青蒿素的晶体结构及其绝对构型.中国科学, 1979, (11):1114-1128.
中医研究院中药研究所药理研究室.青蒿的药理研究.新医药杂志, 1979, (1):23-33.
沈璇坤, 严克东, 罗泽渊, 等.紫外分光光度法测定青蒿素含量.药物分析杂志, 1983, 3(1):24-26.
李英, 虞佩琳, 陈一心, 等.青蒿素类似物的研究--还原青蒿素的醚类/羧酸酯类及碳酸酯类的合成.药学学报, 1981, 16(6):429-439.
顾浩明, 吕宝芬, 瞿志强.青蒿素衍生物对伯氏疟原虫抗氯喹株的抗疟活性.中国药理学报, 1980, 1(1):48-50.
周廷冲, 宋振玉, 周克鼎.世界卫生组织在北京召开青蒿素及其衍生物学术讨论会.药学学报, 1982, 17(2):158-159.
Runhong, LI and Daqing, ZHANG
"Artemisinin: From Traditional Chinese Medicine to Global Antimalarial Drug,"
Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 34
, Article 8.
Available at: https://bulletinofcas.researchcommons.org/journal/vol34/iss9/8