•  
  •  
 

Bulletin of Chinese Academy of Sciences (Chinese Version)

Keywords

laboratory animal; animal models; laboratory animal resources; animal ethics and welfare

Document Type

Article

Abstract

Laboratory animals are important basic supporting conditions for life science and medical research in China. The construction and the scientific and technological innovation of laboratory animals have greatly promoted the development of life science and the construction of Healthy China Initiative. Upon analyzing the developmental status of laboratory animal resource construction internationally and domestically, this article elaborated major issues such as animal resources, laws, ethics, and integrated databases and proposed specific goals and suggestions for the construction of laboratory animal resources in China until 2035. The article hopes to make significant contributions to support the China's life science and medical research by further strengthening the development of laboratory animal resources in China.

First page

1371

Last Page

1378

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

References

国家科技基础条件平台中心.国家科学数据资源发展报告2016.北京:科学技术文献出版社, 2016.

国家科技基础条件平台中心.中国生物种质与实验材料资源发展报告2016.北京:科学技术文献出版社, 2017.

国家科技基础条件平台中心.中国实验动物资源调查与发展趋势.北京:科学出版社, 2017.

中国科学技术协会, 中国实验动物学会. 2014-2015实验动物学学科发展报告.北京:中国科学技术出版社, 2016.

European Mouse Mutant Archive. Access to EMMA mouse resources.[2019-07-22]. https://www.infrafrontier.eu/resources-and-services/access-emma-mouse-resources.

International Mouse Phenotyping Consortium. IMPC Strategy 2021-2030.[2019-07-22]. https://www.mousephenotype.org/news/impc-strategy-2021-2030/.

Wang H, Yang H, Shivalila C S, et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Casmediated genome engineering. Cell, 2013, 153(4):910-918.

Li W, Teng F, Li T, et al. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPRCas systems. Nature Biotechnology, 2013, 31(8):684-686.

Shen B, Zhang J, Wu H, et al. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Research, 2013, 23(5):720-723.

Niu Y, Shen B, Cui Y, et al. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell, 2014, 156(4):836-843.

Liu Z, Cai Y, Wang Y, et al. Cloning of macaque monkeys by somatic cell nuclear transfer. Cell, 2018, 174(4):881-887.

Liu Z, Cai Y, Liao Z, et al. Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer. National Science Review, 2019, 6(1):101-108.

Zheng Q, Lin J, Huang J, et al. Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. PNAS, 2017, 114(45):E9474-9482.

Zhang Y, Xue Y, Cao C, et al. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood, 2017, 130(20):2161-2170.

Yan S, Tu Z, Liu Z, et al. A huntingtin knockin pig model recapitulates features of selective neurodegeneration in Huntington's disease. Cell, 2018, 173(4):989-1002.

Laboratory Animal Resources, Chinese Academy of Sciences. Animal Resources.[2019-07-22]. http://www.lar.ac.cn/animal_resource.

The Jackson Laboratory. Animal Resources.[2019-07-22]. https://www.jax.org/jax-mice-and-services.

Share

COinS