Genome Design and Engineering Construction

Authors

XUE Xiaoli, CAS Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
QIN Zhongjun, CAS Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China

Keywords

genome design; genome deletion; genome synthesis; engineering construction

Document Type

Article

Abstract

Synthetic biology by using engineering ideas to design and construct new biological genomes is the research hotspot in recent years. The de novo synthesis of the prokaryotic Mycoplasma natural minigenome and further design and construction of the minimal genome, the continuous genome deletion of the prokaryotic model organism E. coli and the genome-wide codon simplification design and synthetic test, as well as the artificial design and synthesis tests of the eukaryotic model Saccharomyces cerevisiae genome have achieved great success and greatly promoted our understanding of life. Although the research on the genomes design and engineering construction in China started late, it has achieved internationally remarkable results recently. The genome design and construction provide insight into the origin and evolution of life and lay the foundation for further building a new life with powerful application functions.

First page

1205

Last Page

1210

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

References

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Recommended Citation

Xiaoli, XUE and Zhongjun, QIN (2018) "Genome Design and Engineering Construction," Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 33 : Iss. 11 , Article 8.
DOI: https://doi.org/10.16418/j.issn.1000-3045.2018.11.008
Available at: https://bulletinofcas.researchcommons.org/journal/vol33/iss11/8