Design of Metabolic Engineering Strategies for Biosynthesis of Valuable Products

Authors

MA Hongwu, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China
CHEN Xiulai, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Industrial Biotechnology(Ministry of Education), Jiangnan University, Wuxi 214122, China
YUAN Qianqian, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China
LIU Liming, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Industrial Biotechnology(Ministry of Education), Jiangnan University, Wuxi 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China
SUN Jibin, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

Keywords

computational design; metabolic engineering; biosynthesis; dynamic regulation; metabolic network; synthetic biology

Document Type

Article

Abstract

One main objective of metabolic engineering is to rewire the metabolic network for efficient production of biochemicals. Due to the complexity of cellular metabolic networks, it is often not straightforward to identify the proper modification targets from thousands of metabolic genes. Therefore, a time-consuming trial & error process is often required for the successful development. Aided by computational modeling of large-scale metabolic networks, one can design optimal pathways for synthesis of objective products, reducing the uncertainty of development and thus accelerating the strain construction process. In this short text, we give brief introduction to metabolic engineering design methods from two aspects:how to modify an organism to produce new chemicals with higher yields, and how to improve the cellular adaptation to the changing process conditions by integrating gene circuits. The computer aided design approach together with automated genome edition technologies, will greatly enhance the efficiency of the construction of artificial cell factories.

First page

1166

Last Page

1173

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

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Recommended Citation

Hongwu, MA; Xiulai, CHEN; Qianqian, YUAN; Liming, LIU; and Jibin, SUN (2018) "Design of Metabolic Engineering Strategies for Biosynthesis of Valuable Products," Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 33 : Iss. 11 , Article 4.
DOI: https://doi.org/10.16418/j.issn.1000-3045.2018.11.004
Available at: https://bulletinofcas.researchcommons.org/journal/vol33/iss11/4