synthetic biology; synthetic genetic circuit; reprogramming; environment adaptation; modularization
Genetic circuits are dynamic regulation systems that control the life of every living organism. With the principles of engineering, synthetic genetic circuits are designed through simplifying and re-programming natural genetic circuits, and even by creating completely new principles that does not exist in nature. Genetic circuits are consisting of a wide variety of components, including genetic switches, oscillators, logic gates, and so on. The development of diverse synthetic circuits not only facilitated the understanding of basic principles of life, but also enabled the rebuilding of natural biological systems which has provided brand new solutions for a broad range of applications including medicine, agriculture, and industrial fermentation. In the last two decades, the design of synthetic genetic circuits has been seen rapid development, but the complexity of intercellular biochemical reactions and signal transductions still poses great challenges for building genetic circuits with more sophisticated functions. Consequently, the pathways toward predictable assembly in cells of microscopic scale and ensuring reliable circuit performance in complex environments would be major subjects that challenge all researchers in this field.
Bulletin of Chinese Academy of Sciences
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Chunbo, LOU; Pei, DU; Fankang, MENG; Xiangyu, JI; and Yihao, ZHANG
"Development and Challenges of Synthetic Genetic Circuits,"
Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 33
, Article 3.
Available at: https://bulletinofcas.researchcommons.org/journal/vol33/iss11/3