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Bulletin of Chinese Academy of Sciences (Chinese Version)

Keywords

synthetic biology; ethics; biosafety; biosecurity; regulation

Document Type

Article

Abstract

The rapid development of synthetic biology has aroused widespread concern in the academic community. The engineering properties of synthetic biology individualize it the practical meaning of "design" and "reconstruction". The artificially designed life can be introduced to the traditional DNA-based life evolution process, which may lead to a series of safety risks and ethical arguments. The article explores the controversy caused by the landmark events in the development of synthetic biology, draws in-depth analysis on the safety risks of synthetic biology, as well as the ethical dilemmas and inducements of them. Based on the regulatory mechanism of European countries and U.S., several recommendations were put forward on ethical regulation of synthetic biology in China.

First page

1269

Last Page

1276

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

References

赵国屏.合成生物学的科学内涵和社会意义--合成生物学专刊序言.生命科学, 2011, 23(9):825.

Anderson J, Strelkowa N, Stan G B, et al. Engineering and ethical perspectives in synthetic biology:Rigorous, robust and predictable designs, public engagement and a modern ethical framework are vital to the continued success of synthetic biology. EMBO Reports, 2012, 13(7):584-590.

Shao Y, Lu N, Wu Z, et al. Creating a functional singlechromosome yeast. Nature, 2018(560):331-335.

克雷格·文特尔.生命的未来: 从双螺旋到合成生命.贾拥民, 译.杭州: 浙江人民出版社, 2016: 102, 107.

Cho M K, Magnus D, Caplan A L, et al. Ethical considerations in synthesizing a minimal genome. Science, 1999, 286(5447):2087-2090.

乔治·丘奇.再创世纪: 合成生物学将如何重新创造自然和我们人类.周东, 译.北京: 电子工业出版社, 2017: 84.

Nature. Sizing up the 'synthetic cell'.[2010-05-20]. https://www.nature.com/news/2010/100520/full/news.2010.255.html.

United States, Presidential Commission for the Study of Bioethical Issues. New directions:the ethics of synthetic biology and emerging technologies. Jahrbuch Für Wissenschaft Und Ethik, 2012, 16(1):557-566.

华商报.人造生命在美诞生能够自己生长繁殖.[2010-05-23]. http://finance.ifeng.com/money/roll/20100523/2222416.shtml.

ETC Group, Friends of the Earth, et al. The principles for the oversight of synthetic biology.[2012-12-01]. http://www.etcgroup.org/content/principles-oversight-synthetic-biology.

Mullin E. Designer chromosomes point to new synthetic lifeforms.[2017-03-09]. https://www.technologyreview.com/s/603815/designer-chromosomes-point-to-new-synthetic-lifeforms/.

王朝恩, 周爱萍.车库生物学:挑战与规制.科学与社会, 2013, 3(1):86-96.

Natioanl Science Advisory Board for Biosecurity. Addressing Biosecurity Concerns Related to Synthetic Biology: report of NSABB.[2010-04-01]. https://osp.od.nih.gov/wp-content/uploads/NSABB_SynBio_DRAFT_Report-FINAL-2_6-7-10.pdf.

Department of Health and Human Services, National Institutes of Health. NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines).[2016-04-01]. https://osp.od.nih.gov/wp-content/uploads/NIH_Guidelines.html.

赵鲁.实验室SARS病毒泄漏事故回顾.[2014-07-25]. http://news.sciencenet.cn/htmlnews/2014/7/299630.shtm.

Selgelid M J. Governance of dual-use research:an ethical dilemma. Bulletin of the World Health Organization, 2009, 87(9):720-723.

National Academies of Sciences, Engineering, and Medicine. Biodefense in the Age of Synthetic Biology. Washington D C:The National Academies Press, 2018.

乌尔里希.贝克.风险社会.何博闻, 译.北京: 译林出版社, 2004.

刘玉强.社会实验:作为一种技术治理路径--以氟氯烃的社会引入为例.自然辩证法研究, 2017, 33(4):63-67.

翟晓梅, 邱仁宗.合成生物学:伦理和管治问题.科学与社会, 2014, 4(4):48.

DFG. Synthetic Biology-Opportunities and Risks.[2009-07-27]. http://www.dfg.de/en/service/press/press_releases/2009/pressemitteilung_nr_37a/index.html.

Capurro R, Kinderlerer J, Silva P D, et al. Ethics of synthetic biology.[2009-11-17]. https://www.erasynbio.eu/lw_resource/datapool/_items/item_15/ege__opinion25_en.pdf.

Pauwels K, Willemarck N, Breyer D, et al. Synthetic Biology: Latest developments, biosafety considerations and regulatory challenges.[2012-09-01]. https://www.biosafety.be/sites/default/files/120911_doc_synbio_sbb_final.pdf.

Buhk H J. Synthetic biology and its regulation in the European Union. New Biotechnology, 2014, 31(6):528-531.

Trump B D. Synthetic biology regulation and governance:Lessons from TAPIC for the United States, European Union, and Singapore. Health Policy, 2017, 121(11):1139-1146.

ETC Group. Four Steps Forward, One Leap Back on Global Governance of Synthetic Biology[2016-12-19]. http://www.etcgroup.org/content/four-steps-forward-one-leap-back-globalgovernance-synthetic-biology.

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