synthetic biology; biofoundry; engineering platform
In the field of synthetic biology research, the massive scale of trial-and-error experiments in engineering goes far beyond the traditional labor-intensive research paradigm, so it needs a transformative engineering research platform. With the introduction of various types of intelligent equipment to meet the production needs, engineering platforms carry out a large-scale of customization and research paradigm innovation, to realize the remote customization, offsite design, and economic scale production of organisms. Engineering platforms can accumulate experience and knowledge quickly, and serve as the scientific basis for the predictive synthesis of organisms. This article will introduce some cases and development trends of engineering platforms, as well as upstream and downstream institutions for synthetic biology research.
Bulletin of Chinese Academy of Sciences
Clarke L J, Kitney R I. Synthetic biology in the UK-An outline of plans and progress. Synthetic and Systems Biotechnology, 2016, 1(4):243-257.
晁然, 原永波, 赵惠民.构建合成生物学制造厂.中国科学:生命科学, 2015, 45(10):976-984.
Le Feuvre R A, Scrutton N S. A living foundry for Synthetic Biological Materials:A synthetic biology roadmap to new advanced materials. Synthetic and Systems Biotechnology, 2018, 3(2):105-112.
DARPA's Living Foundries Project Report.[2018-10-26]. https://www.darpa.mil/program/living-foundries.
Eric Lax. The Mold in Dr. Florey's Coat:The Story of the Penicillin Miracle. New York:Henry Holt and Company, 2004.
Morrell W C, Birkel G W, Forrer M, et al. The experiment data depot:a web-based software tool for biological experimental data storage, sharing, and visualization. ACS Synthetic Biology, 2017, 6(12):2248-2259.
Jinming, CUI; Bingzhao, ZHANG; Yingfei, MA; Xiongfei, FU; Meng, WANG; and Chenli, LIU
"Engineering Platforms for Synthetic Biology Research,"
Bulletin of Chinese Academy of Sciences (Chinese Version): Vol. 33
, Article 13.
Available at: https://bulletinofcas.researchcommons.org/journal/vol33/iss11/13