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Bulletin of Chinese Academy of Sciences (Chinese Version)

Keywords

nanozymes, new materials, natural enzymes, catalysis, artificial enzymes, interdisciplinary

Document Type

High Ground of Science and Innovation

Abstract

Nanozymes represent a novel class of artificial enzymes and biocatalysts, possessing both the physical and chemical properties of nanomaterials along with unique enzyme-like catalytic activities, which breaks the boundary between inorganic materials and organic life. Unlike natural enzymes, traditional enzyme mimics and chemical catalysts, nanozymes exhibit catalytic activity that can be regulated by their nanoscale physical and chemical properties. They are characterized by good stability, high- and lowtemperature resistance, acid and alkali resistance, adjustable activity, and multifunctionality. As a result, nanozymes have garnered widespread attention in the fields of biomedicine, environment treatment, green agriculture, new energy resources, and have begun to establish a disciplinary framework. This review aims to provide an overview of the discovery, disciplinary characteristics, and framework of nanozymes, as well as their applications and future development prospects, in order to advance our understanding and promote further development in this field.

First page

809

Last Page

820

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

References

1 Gao L Z, Zhuang J, Nie L, et al. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nature Nanotechnology, 2007, 2(9): 577-583.

2 Wei H, Wang E K. Nanomaterials with enzyme-like characteristics (nanozymes): Next-generation artificial enzymes. Chemical Society Reviews,2013, 42(14): 6060-6093.

3 Mo W C, Yu J, Gao L Z, et al. Reversible inhibition of iron oxide nanozyme by guanidine chloride. Frontiers in Chemistry, 2020, 8: 491.

4 Chen Y, Tian Q, Wang H Y, et al. A manganese-based metal-organic framework as a cold-adapted nanozyme. Advanced Materials, 2024, 36(10): e2206421.

5 Yan X. Nanozymology: Connecting Biology and Nanotechnology. Singapore: Springer Singapore, 2020.

6 Li J Q, Cai X D, Jiang P, et al. Co-based nanozymatic profiling: Advances spanning chemistry, biomedical, and environmental sciences. Advanced Materials, 2024, 36(8): 2307337.

7 Wei H, Gao L Z, Fan K L, et al. Nanozymes: A clear definition with fuzzy edges. Nano Today, 2021, 40: 101269.

8 Gomollón-Bel F. IUPAC Top Ten Emerging Technologies in Chemistry 2022: Discover the innovations that will transform energy, health, and materials science, to tackle the most urgent societal challenges and catalyze sustainable development. Chemistry International, 2022, 44(4): 4-13.

9 高利增, 阎锡蕴. 纳米酶的发现与应用. 生物化学与生物物理进展, 2013, 40(10): 892-902.Gao L Z, Yan X Y. Discovery and current application of nanozyme. Progress in Biochemistry and Biophysics, 2013, 40(10): 892-902. (in Chinese)

10 王孜丹, 赵超, 张理茜, 等. 优化自然科学基金学科布局的改革逻辑与路径选择. 中国科学基金, 2019, 33(5): 440-445.Wang Z D, Zhao C, Zhang L Q, et al. Reform logic and path choice for optimizing the discipline layout of science funds. Bulletin of National Natural Science Foundation of China, 2019, 33(5): 440-445. (in Chinese)

11 Li J H. Exploring the logic and landscape of the knowledge system: Multilevel structures, each multiscaled with complexity at the mesoscale. Engineering, 2016, 2(3): 276-285.

12 梁敏敏, 孟凡霞. 纳米酶:中国原创领域的机遇与挑战——香山科学会议第606次学术研讨会简报. 生物化学与生物物理进展, 2018, 45(2): 272-276.Liang M M, Meng F X. Nanoenzyme: Opportunities and challenges in China’s original field—Briefing on the 606th symposium of Xiangshan science conference. Progress in Biochemistry and Biophysics, 2018, 45(2): 272-276. (in Chinese)

13 范克龙, 高利增, 魏辉, 等. 纳米酶. 化学进展, 2023, 35(1): 1-87.Fan K L, Gao L Z, Wei H, et al. Nanozymes. Progress in Chemistry, 2023, 35(1): 1-87. (in Chinese)

14 Wang Z R, Zhang R F, Yan X Y, et al. Structure and activity of nanozymes: Inspirations for de novo design of nanozymes. Materials Today, 2020, 41: 81-119.

15 高利增, 陈雷, 张若飞, 等. 纳米酶:新一代人工酶. 中国科学: 化学, 2022, 52(9): 1649 -1663.Gao L Z, Chen L, Zhang R F, et al. Nanozymes: Next-generation artificial enzymes. Scientia Sinica (Chimica), 2022, 52(9): 1649-1663. (in Chinese)

16 Zhang R F, Yan X Y, Fan K L. Nanozymes inspired by natural enzymes. Accounts of Materials Research, 2021, 2(7): 534-547.

17 焦健, 范克龙, 胡志刚, 等. 纳米酶的发展态势与优先领域分析. 中国科学:化学, 2019, 49(12): 1442-1453.Jiao J, Fan K L, Hu Z G, et al. Development trend and priority areas of nanozyme. Scientia Sinica Chimica), 2019, 49(12): 1442-1453. (in Chinese)

18 Huang Y Y, Ren J S, Qu X G. Nanozymes: Classification, catalytic mechanisms, activity regulation, and applications. Chemical Reviews, 2019, 119(6): 4357-4412.

19 Wang M T, Liu H X, Fan K L. Signal amplification strategy design in nanozyme-based biosensors for highly sensitive detection of trace biomarkers. Small Methods, 2023, 7(11): 2301049.

20 Mou X Z, Wu Q Y, Zhang Z A, et al. Nanozymes for regenerative medicine. Small Methods, 2022, 6(11): 2200997.

21 Zhou C Y, Wang Q, Jiang J, et al. Nanozybiotics: Nanozyme-based antibacterials against bacterial resistance. Antibiotics, 2022, 11(3): 390..

22 Maher B A, Ahmed I A M, Karloukovski V, et al. Magnetite pollution nanoparticles in the human brain. PNAS, 2016, 113(39): 10797-10801.

23 Zhao L J, Bai T H, Wei H, et al. Nanobiotechnology-based strategies for enhanced crop stress resilience. Nature Food, 2022, 3: 829-836.

24 李芙蓉, 向发椿, 曹丽萍, 等. 纳米酶在食品检测中的应用研究进展. 食品科学, 2022, 43(1): 285-297.Li F R, Xiang F C, Cao L P, et al. Recent advances in applications of nanozymes in food detection. Food Science, 2022, 43(1): 285-297. (in Chinese)

25 Hong C Y, Meng X Q, He J Y, et al. Nanozyme: A promising tool from clinical diagnosis and environmental monitoring to wastewater treatment. Particuology, 2022, 71: 90-107.

26 Wu X T, Zhang R F, Yan X Y, et al. Nanozyme: A new approach for anti-microbial infections. Journal of Inorganic Materials, 2023, 38(1): 43-54.

27 Natalio F, André R, Hartog A F, et al. Vanadium pentoxide nanoparticles mimic vanadium haloperoxidases and thwart biofilm formation. Nature Nanotechnology, 2012, 7(8): 530-535.

28 Yuan Y, Chen L, Kong L F, et al. Histidine modulates amyloid-like assembly of peptide nanomaterials and confers enzyme-like activity. Nature Communications, 2023, 14(1): 5808.

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