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Bulletin of Chinese Academy of Sciences (Chinese Version)

Keywords

environmental pollution; health effect; exposure; etiology; toxicology

Document Type

S & T and Society

Abstract

The complex environmental pollution in China greatly threatens the human health. Although the pollution control policies have taken a great effect in recent years, the resultant long-term, chronic health risks are still concerned. Until now, the causes of many regional high-incidence diseases are still unclear. In order to solve these environmental health problems, we need multi-disciplinary innovations in basic research to establish the comprehensive research chain of "pollution process-human exposure-body response-disease development". We need breakthroughs in interdisciplinary fields including exposomics, ultratrace measurement and source tracing methodology, molecular epidemiology, environmental big data, and artificial intelligence. Only in this way can we achieve the health risk-oriented precise prevention and control of environmental pollution.

First page

614

Last Page

621

Language

Chinese

Publisher

Bulletin of Chinese Academy of Sciences

References

1 江桂斌, 宋茂勇. 环境暴露与健康效应. 北京:科学出版社, 2020.

2 Manolio T A, Bailey-Wilson J E, Collins F S. Genes, environment and the value of prospective cohort studies. Nature Reviews Genetics, 2006, 7(10):812-820.

3 Rappaport S M, Smith M T. Environment and disease risks. Science, 2010, 330:460-461.

4 Zhang S W, Sun K X, Zheng R S, et al. Cancer incidence and mortality in China, 2015. Journal of the National Cancer Center, 2021, 1(1):2-11.

5 Cohen A J, Brauer M, Burnett R, et al. Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution:An analysis of data from the Global Burden of Diseases Study 2015. The Lancet, 2017, 389:1907-1918.

6 Zhou M G, Wang H D, Zeng X Y, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017:A systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 2019, 394:1145-1158.

7 Baumgartner J, Zhang Y, Schauer J J, et al. Highway proximity and black carbon from cookstoves as a risk factor for higher blood pressure in rural China. PNAS, 2014, 111(36):13229-13234.

8 Chen H, Kwong J C, Copes R, et al. Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis:A population-based cohort study. The Lancet, 2017, 389:718-726.

9 Tomasetti C, Vogelstein B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science, 2015, 347:78-81.

10 Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science, 2017, 355:1330-1334.

11 Wu S, Powers S, Zhu W, et al. Substantial contribution of extrinsic risk factors to cancer development. Nature, 2016, 529:43-47.

12 赫捷, 陈万青. 2012中国肿瘤登记年报. 北京:军事医学科学出版社, 2013.

13 Mumford J L, He X Z, Chapman R S, et al. Lung cancer and indoor air pollution in Xuan Wei, China. Science, 1987, 235:217-220.

14 Li J H, Ran J J, Chen L C, et al. Bituminous coal combustion and Xuan Wei Lung cancer:A review of the epidemiology, intervention, carcinogens, and carcinogenesis. Archives of Toxicology, 2019, 93(3):573-583.

15 Bloszies C S, Fiehn O. Using untargeted metabolomics for detecting exposome compounds. Current Opinion in Toxicology, 2018, 8:87-92.

16 Wild C P. Complementing the genome with an ""exposome"":The outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiology, Biomarkers & Prevention, 2005, 14(8):1847-1850.

17 Lu D W, Luo Q, Chen R, et al. Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion. Nature Communications, 2020, 11:2567.

18 Liu Q, Hintelmann H, Jiang G B. Natural stable isotopes:New tracers in environmental health studies. National Science Review, 2016, 3(4):410.

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